Schizophrenia and brain volume genetic covariation
نویسندگان
چکیده
منابع مشابه
Imaging the Brain as Schizophrenia Develops: Dynamic & Genetic Brain Maps.
Schizophrenia is a chronic, debilitating psychiatric disorder that affects 0.2-2% of the population worldwide. Often striking without warning in the late teens or early twenties, its symptoms include auditory and visual hallucinations, psychotic outbreaks, bizarre or disordered thinking, depression and social withdrawal. To combat the disease, new antipsychotic drugs are emerging; these atypica...
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Despite a high prevalence of schizophrenia patients with comorbid substance abuse, little is known about possible impacts on the brain. Hence, our goal was to determine whether addicted and non-addicted schizophrenic patients suffer from different brain deficits. We were especially interested to determine if grey matter volumes were affected by impulsivity. We hypothesized that (comorbid) subst...
متن کاملCompounded brain volume deficits in schizophrenia-alcoholism comorbidity.
BACKGROUND Schizophrenia and alcoholism are characterized by brain volume abnormalities. Despite the frequent comorbidity of these conditions, the potentially compounded effects of comorbidity on brain structure have seldom been rigorously assessed. METHODS To determine the compounding effect of schizophrenia and alcoholism on regional brain volumes, we performed retrospective quantitative an...
متن کاملGenetic and environmental covariation between autistic traits and behavioral problems.
Our objective was to examine the overlap between autistic traits and other behavioral problems in a general population sample, and explore the extent to which this overlap is due to genetic or environmental factors. Youth Self Report (YSR) data were collected in a general population sample of 424 twin pairs at 18 years of age, and their nontwin siblings. In 197 of these twin families, self-repo...
متن کاملStructural Brain Connectivity as a Genetic Marker for Schizophrenia.
IMPORTANCE Schizophrenia is accompanied by a loss of integrity of white matter connections that compose the structural brain network, which is believed to diminish the efficiency of information transfer among brain regions. However, it is unclear to what extent these abnormalities are influenced by the genetic liability for developing the disease. OBJECTIVE To determine whether white matter i...
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ژورنال
عنوان ژورنال: Nature Neuroscience
سال: 2016
ISSN: 1097-6256,1546-1726
DOI: 10.1038/nn0316-419